The main focus of our research is the development of new methods for nuclear magnetic resonance (NMR) spectroscopy and the application this technique to a variety of chemical and biological problems.
NMR spectroscopy is a highly informative technique that is one of the main analytical tools in the sciences. Over the past thirty years, the development of Fourier transform and multidimensional methods has led to the application of NMR spectroscopy to a wide range of problems, including chemical analysis, screening drug targets, the determination of protein structures, understanding fluid dynamics, and medicine (where it is known as MRI: magnetic resonance imaging).
Examples of research directions in the group have included:
- New pulse sequences that can determine the same information as current experiments but in a greatly reduced amount of time.
- Methods that increase the rate at which experiments can be repeated.
- Identification of biological molecules.
- Improved chemical shift thermometers.
- Quantification of metabolites in tissue samples.
- Determining the structures of proteins and peptides.